Hydrochloric Acid → HCID 67519703, compound

HRID 12763Notes

Reaction equation

HRID 12763 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[C:8](=[O:34])[NH:9][C:10](=[O:33])[N:11]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][C@H:21]3[C@:19]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)([CH2:20]3)[CH2:18]2)[CH:12]=1.[ClH:35]>O1CCOCC1>[ClH:35].[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[C:8](=[O:34])[NH:9][C:10](=[O:33])[N:11]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][C@H:21]3[C@:19]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:32])[F:31])=[CH:25][CH:24]=4)([CH2:20]3)[CH2:18]2)[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 247591155-(3-methyl-2-thienyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 67519703HCID 67519703, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5-(3-methyl-2-thienyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (200 μl) to give the title compound as a white solid.

Sources & evidence

ORD record
ord-77adce4336454244bc5b05e58fa49b8e
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

Loading…