2-(2-Chloroethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxy-1-ethyl)-3,3,7-trimethyl-1,3-dihydro-2H-indol-2-one

HRID 1276323Notes

Reaction equation

HRID 1276323 reaction equation
[CH3:1][C:2]1([CH3:13])[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:12].Cl[CH2:15][CH2:16][O:17]C1CCCCO1>>[OH:17][CH2:16][CH2:15][N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][C:6]=2[CH3:11])[C:2]([CH3:13])([CH3:1])[C:3]1=[O:12]

Participants

3

Reactant 2

HCID 2549512-(2-Chloroethoxy)tetrahydro-2H-pyranHCID 151874723,3,7-Trimethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 221161181-(2-Hydroxy-1-ethyl)-3,3,7-trimethyl-1,3-dihydro-2H-indol-2-one

Procedure

Prepared from 3,3,7-trimethyl-1,3-dihydro-2H-indol-2-one (prepared by the method of Endler and Becker; Organic Syntheses Coll. vol. 4 page 657) and 2-(2-chloroethoxy)tetrahydro-2H-pyran as described above.

Workup

  1. customprepared by the method of Endler and Becker

Sources & evidence

ORD record
ord-e92c76d4f1cd4485877c8e5ec2076384
Source dataset
uspto-grants-2000_12
Patent number
US06166040

Reaction notes

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