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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1276323Generated: November 1, 2026

2-(2-Chloroethoxy)tetrahydro-2H-pyran → 1-(2-Hydroxy-1-ethyl)-3,3,7-trimethyl-1,3-dihydro-2H-indol-2-one

https://huagongshe.com/reaction/1276323

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Chloroethoxy)tetrahydro-2H-pyranHCID 254951—
Reactant3,3,7-Trimethyl-1,3-dihydro-2H-indol-2-oneHCID 15187472—
Product1-(2-Hydroxy-1-ethyl)-3,3,7-trimethyl-1,3-dihydro-2H-indol-2-oneHCID 22116118—

Reaction Steps

Prepared from 3,3,7-trimethyl-1,3-dihydro-2H-indol-2-one (prepared by the method of Endler and Becker; Organic Syntheses Coll. vol. 4 page 657) and 2-(2-chloroethoxy)tetrahydro-2H-pyran as described above.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06166040
Source datasetuspto-grants-2000_12
ORD IDord-e92c76d4f1cd4485877c8e5ec2076384
Source noteuspto-grants-2000_12