反应详情

4-(7-Fluoroindol-3-yl)-1,2,5,6-tetrahydropyridine (2.0 g, 9.26 mmols), 3,3-dimethyl-1-(2-methanesulfonyloxy-1-ethyl)-1,3-dihydro-2H-indol-2-one (2.623 g, 9.26 mmols), sodium carbonate (2.947 g,27.8 mmols),water (20 mls) combined and heated to 90 deg C. for 3 hours. Extracted into ethyl acetate (2×50 ml). Dried (MgSO4),filtered and concentrated in vacuo. The resultant solid was recrystallised from ethyl acetate and then converted to the hydrochloride salt (0.85 g).m.p 235-236 deg. C.

1. temperatureheated to 90 deg C
2. extractionExtracted into ethyl acetate (2×50 ml)
3. concentrationDried (MgSO4),filtered and concentrated in vacuo
4. customThe resultant solid was recrystallised from ethyl acetate
5. customconverted to the hydrochloride salt (0.85 g).m.p 235-236 deg. C