Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 3,3-Dimethyl-1-{2-[4-(7-fluoroindol-3-yl)-1,2,5,6-tetrahydro-1-pyridyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 7-Fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 12083453 | — |
| 반응물 | 3,3-dimethyl-1-(2-methanesulfonyloxy-1-ethyl)-1,3-dihydro-2H-indol-2-one | HCID 22116105 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3,3-Dimethyl-1-{2-[4-(7-fluoroindol-3-yl)-1,2,5,6-tetrahydro-1-pyridyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one | HCID 9865888 | — |
반응 단계
4-(7-Fluoroindol-3-yl)-1,2,5,6-tetrahydropyridine (2.0 g, 9.26 mmols), 3,3-dimethyl-1-(2-methanesulfonyloxy-1-ethyl)-1,3-dihydro-2H-indol-2-one (2.623 g, 9.26 mmols), sodium carbonate (2.947 g,27.8 mmols),water (20 mls) combined and heated to 90 deg C. for 3 hours. Extracted into ethyl acetate (2×50 ml). Dried (MgSO4),filtered and concentrated in vacuo. The resultant solid was recrystallised from ethyl acetate and then converted to the hydrochloride salt (0.85 g).m.p 235-236 deg. C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06166040 |
| 출처 데이터셋 | uspto-grants-2000_12 |
| ORD ID | ord-79d85607ce6e4207bc0d17bcd9c36a07 |
| 출처 메모 | uspto-grants-2000_12 |