Oxalyl chloride → HCID 22116155, compound

HRID 1276380Notes

Reaction equation

HRID 1276380 reaction equation
C(Cl)(=O)C([Cl:4])=O.[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:16]([CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:32][CH2:33][C:34]([F:37])([F:36])[F:35])[C:29](O)=[O:30])=[CH:23][CH:22]=1)[CH3:17]>C1C=CC=CC=1>[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[N:16]([CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:32][CH2:33][C:34]([F:37])([F:36])[F:35])[C:29]([Cl:4])=[O:30])=[CH:23][CH:22]=1)[CH3:17]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 11826270HCID 11826270, compound

Product 1

HCID 22116155HCID 22116155, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Oxalyl chloride (1.1 mL) was added to a solution of (±)-3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid (1.72 g) in dry benzene (30 mL). The mixture was heated at reflux for 2 hours, cooled and evaporated to dryness to give the title compound as a gum which was used without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 2 hours
  3. temperaturecooled
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-db0c35261d4547819be2ecc7cfe7675b
Source dataset
uspto-grants-2000_12
Patent number
US06166049

Reaction notes

Loading…