反应详情

A mixture of 5 ml of cyclopropylamine and 10 ml of water was added to a solution of 1 gram (3.9 mmole) of 3-tert-butylsulfamoyl-benzenesulfonyl chloride in ethyl acetate. The mixture was stirred at room temperature for 2 hours. The ethyl acetate layer was separated, dried over magnesium sulfate and concentrated in vacuo to an oil which crystallized from isopropyl ether to give 839 mg of the titled compound as a solid.

1. customThe ethyl acetate layer was separated
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated in vacuo to an oil which
4. customcrystallized from isopropyl ether