Sodium Hydroxide → HCID 54280196, compound

HRID 1276530Notes

Reaction equation

HRID 1276530 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([F:17])=[C:10]([S:13]([NH2:16])(=[O:15])=[O:14])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)(=O)C>[F:17][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[S:13]([NH2:16])(=[O:15])=[O:14])[NH:4][CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 545506451-Acetyl-5-fluoro-2,3-dihydro-1H-indole-6-sulfonic acid amide

Product 1

HCID 54280196HCID 54280196, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.6 grams of 1-Acetyl-5-fluoro-2,3-dihydro-1H-indole-6-sulfonic acid amide and 30 ml of 2N sodium hydroxide was heated at 100° C. for 3 hours. The reaction was cooled and the pH was adjusted to 7.0 with acetic acid. The resulting precipitate was filtered to give 3.0 grams of the titled compound.

Workup

  1. temperatureThe reaction was cooled
  2. filtrationThe resulting precipitate was filtered

Sources & evidence

ORD record
ord-be50d3691f3c429f8f8b1f2691f14de0
Source dataset
uspto-grants-2000_12
Patent number
US06166064

Reaction notes

Loading…