Chloroacetyl chloride → HCID 22116584, compound

HRID 1276624Notes

Reaction equation

HRID 1276624 reaction equation
[NH2:1][CH:2]1[C:8]2[CH:9]=[C:10]([Cl:13])[CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5][C:4]2[CH:14]=[CH:15][CH:16]=[CH:17][C:3]1=2.Cl[CH2:19][C:20](Cl)=O.[NH:23]1[CH2:28][CH2:27][C:26]2([C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30](=[O:37])[O:29]2)[CH2:25][CH2:24]1>>[ClH:13].[Cl:13][C:10]1[CH:11]=[CH:12][C:7]2[CH2:6][CH2:5][C:4]3[CH:14]=[CH:15][CH:16]=[CH:17][C:3]=3[CH:2]([NH:1][CH2:19][CH2:20][N:23]3[CH2:28][CH2:27][C:26]4([C:36]5[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=5)[C:30](=[O:37])[O:29]4)[CH2:25][CH2:24]3)[C:8]=2[CH:9]=1

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 98342553H-spiro(isobenzofuran-1,4'-piperidin)-3-oneHCID 12489093HCID 12489093, compound

Product 1

HCID 22116584HCID 22116584, compound

Procedure

The title compound, m.p. 228° C. and MS: m/e=473 (M+H+), was prepared in accordance with the general method of example 1 from 5-amino-3-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene, chloroacetyl chloride, spiro[isobenzofuran-1(3H),4'-piperidin]-3-one and Hcl.

Sources & evidence

ORD record
ord-f0a274ad5ac14150835dfa92955761f8
Source dataset
uspto-grants-2000_12
Patent number
US06166209

Reaction notes

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