HCID 15888208, compound → 122331-77-5

HRID 1276673Notes

Reaction equation

HRID 1276673 reaction equation
[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH3:41])=[C:10]([CH:40]=2)[C@@H:11]([C:28]2[C:37]([CH3:38])=[CH:36][C:31]([C:32]([O:34]C)=[O:33])=[CH:30][C:29]=2[CH3:39])[O:12]C(=O)[C@@H](NS(C2C=CC(Cl)=CC=2)(=O)=O)C)[CH:5]=[CH:4][N:3]=[CH:2]1>CN(C)C=O>[OH:12][C@H:11]([C:28]1[C:29]([CH3:39])=[CH:30][C:31]([C:32]([OH:34])=[O:33])=[CH:36][C:37]=1[CH3:38])[C:10]1[CH:40]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:7]=[CH:8][C:9]=1[CH3:41]

Participants

3

Reactant 1

HCID 15888208HCID 15888208, compound

Product 1

HCID 11056808122331-77-5

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Example 3 was treated in the same manner as in Example 2 to give 2.4 g of (S)-4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid, melting point 286-288° C. (decomposition), optical rotation [α]D21 -261.5° (c=1.0, dimethylformamide).

Sources & evidence

ORD record
ord-7af770514fa54686ac631777c3ec64c3
Source dataset
uspto-grants-2000_12
Patent number
US06166221

Reaction notes

Loading…