Sodium Hydroxide → 2,4-Difluoro-6-hydroxybenzoic acid
Reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7](F)[C:3]=1[C:4]([OH:6])=[O:5].[OH-:13].[Na+]>CN1CCCC1=O>[F:11][C:9]1[CH:8]=[C:7]([OH:13])[C:3](=[C:2]([F:1])[CH:10]=1)[C:4]([OH:6])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
1.76 g (0.01 mole) of 2,4,6-trifluorobenzoic acid, 1.62 g (0.04 mole) of powdery 99% sodium hydroxide and 20 ml of 1-methyl-2-pyrrolidone were fed into a 100-ml four-necked flask provided with a thermometer, a stirrer and a reflux condenser. The mixture was stirred at 130° C. for 3 hours to give rise to a reaction. Then, the same post-treatment as in Example 2 was conducted to obtain 1.47 g of 4,6-difluorosalicylic acid. The isolated yield was 84.3% relative to the 2,4,6-trifluorobenzoic acid used.
Workup
- customprovided with a thermometer, a stirrer and a reflux condenser
- customto give rise
- customto a reaction
Sources & evidence
- ORD record
- ord-793d0ad968124d1b8df1a8a480b26712
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06166246
Reaction notes
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