反应详情

Into 30 ml of dioxane were suspended 1.3 g of 5-fluorouracil. To this suspension were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 5 hours at 170° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.40 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.10 g of 1-(2-tetrahydrofuryl)-5-fluorouracil was obtained. The yield of the end product was 79.5% based on the consumed 5-fluorouracil.

1. customthe mixture was reacted in an autoclave for 5 hours at 170° C
2. customAfter completion of the reaction
3. customthe reaction liquid
4. additionwas treated in the same manner
5. customwas recovered as a substance insoluble in chloroform