反应详情

N-1-butanesulfonyl-3-(2,4-dichlorobenzylamino)-4-nitrobenzamide (0.505 g) was added to a mixture of 1.32 g of sodium hydrosulfite, 1 ml of ethanol, 1 ml of tetrahydrofuran and 1 ml of water at room temperature. The mixture was heat-refluxed for 40 minutes. The solvent was distilled off under reduced pressure, and water was added to the residue. The solid material precipitated was collected, and was dried. Further, the resulting material was washed with a mixed solution of 10 ml of methanol and 3 ml of water, and was dried to give 0.220 g of N-1-butanesulfonyl-4-amino-3-(2,4-dichlorobenzylamino)benzamide.

1. temperatureThe mixture was heat-refluxed for 40 minutes
2. distillationThe solvent was distilled off under reduced pressure, and water
3. additionwas added to the residue
4. customThe solid material precipitated
5. customwas collected
6. customwas dried
7. washFurther, the resulting material was washed with a mixed solution of 10 ml of methanol and 3 ml of water
8. customwas dried