反应详情

5-Iodo-1-{3-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-propyl}-1H-pyrimidine-2,4-dione (Prep40, 46 mg, 0.09 mmol) was dissolved in degassed DME-water solution (5-1, 1 mL). Pyridine 4-boronic acid (22 mg, 0.18 mmol), Na2CO3 (20 mg, 0.18 mmol), 2-(dicyclohexylphosphino)biphenyl (7 mg, 0.02 mmol) and Pd(PPh3)4 (20 mg, 0.02 mmol) were added and the mixture was placed in a microwave oven and heated at 150° for 20 minutes. The mixture was diluted with ethyl acetate, and washed with water. The organic phase was dried (Na2SO4) and evaporated; the crude was dissolved in MeOH and loaded on SCX cartridge washing with MeOH and eluting with MeOH/NH3 95:5. The residue was purified by flash chromatography with DCM-MeOH—NH4OH (99-1-0.1) to give the title compound (13 mg, 32% yield) as free base.

1. customthe mixture was placed in a microwave oven
2. temperatureheated at 150° for 20 minutes
3. washwashed with water
4. dry with materialThe organic phase was dried (Na2SO4)
5. customevaporated
6. dissolutionthe crude was dissolved in MeOH
7. washwashing with MeOH
8. washeluting with MeOH/NH3 95:5
9. customThe residue was purified by flash chromatography with DCM-MeOH—NH4OH (99-1-0.1)