Methyl iodide → HCID 21268026, compound

HRID 1277042Notes

Reaction equation

HRID 1277042 reaction equation
[CH:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH2:11][CH2:12][C:13]([C:17]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([CH2:26][N:27]5[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]5)=[CH:22][CH:21]=4)=[O:18])=[CH:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:33][I:34]>CN(C=O)C>[I-:34].[CH:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH2:11][CH2:12][C:13]([C:17]([NH:19][C:20]4[CH:21]=[CH:22][C:23]([CH2:26][N+:27]5([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]5)=[CH:24][CH:25]=4)=[O:18])=[CH:14]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18472430HCID 18472430, compound

Product 1

HCID 21268026HCID 21268026, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF (2 ml) was dissolved 7-cyclohexyl-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide (120 mg), and to the mixture was added methyl iodide (45 μl). The mixture was stirred at room temperature for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give 1-[4-(7-cyclohexyl-3,4-dihydro-naphthalene-2-carboxamido) benzyl]-1 -methylpiperidinium iodide (Compound 2) (148 mg) as colorless crystals.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-ffbabe3c09c14971a6b5f8fc79aab693
Source dataset
uspto-grants-2000_12
Patent number
US06166006

Reaction notes

Loading…