HCID 14083133, compound → HCID 23453547, compound

HRID 1277341Notes

Reaction equation

HRID 1277341 reaction equation
[C:1]1([CH2:7][CH:8]([N:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:24]([CH:31]([C:36]([C:43]([O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:44])([C:40](Cl)=[O:41])[CH:37]([F:39])[F:38])[C:32]([O:34][CH3:35])=[O:33])C1C=CC=CC=1.ClC(C(C(F)F)C(C)C(OC)=O)=O>>[CH:17](=[N:16][C:8]([CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:40](=[O:41])[C:36]([C:43]([O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:44])([CH:37]([F:39])[F:38])[CH:31]([CH3:24])[C:32]([O:34][CH3:35])=[O:33])[C:9]([O:11][C:12]([CH3:15])([CH3:13])[CH3:14])=[O:10])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 14083133HCID 14083133, compoundHCID 23453518HCID 23453518, compoundHCID 53920612HCID 53920612, compound

Product 1

HCID 23453547HCID 23453547, compound

Procedure

1-t-butyl 6-methyl 2-benzylideneamino-2-benzyl-4-benzyloxycarbonyl-4-difluoromethyl-5-methyl-3-oxohexanedioate is prepared in a similar manner except that t-butyl 3-phenyl-2-benzylideneaminopropionate is used in place of t-butyl 2-benzylideneaminopropionate and methyl 2-benzyl-3-benzyloxycarbonyl-3-chloroformyl-4,4-difluorobutanoate and methyl 3-benzyloxycarbonyl-3-chloroformyl-4,4-difluoro-2-methyl butanoate are used respectively in place of methyl 3-chloroformyl-4,4-difluoro-2-methylbutanoate.

Sources & evidence

ORD record
ord-7f46a32becb34688927dcf86a65e425f
Source dataset
uspto-grants-1981_07
Patent number
US04277395

Reaction notes

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