Lithium Hydroxide → HCID 23453516, compound

HRID 1277343Notes

Reaction equation

HRID 1277343 reaction equation
C([O:3][C:4](=[O:24])[CH:5]([CH2:17]C1C=CC=CC=1)[CH:6]([C:9]1([C:15]#[N:16])[S:14][CH2:13][CH2:12][CH2:11][S:10]1)[CH2:7][F:8])C.[OH-].[Li+]>C(O)C>[C:15]([C:9]1([CH:6]([CH2:7][F:8])[CH:5]([CH3:17])[C:4]([OH:24])=[O:3])[S:10][CH2:11][CH2:12][CH2:13][S:14]1)#[N:16]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 53769784HCID 53769784, compound

Product 1

HCID 23453516HCID 23453516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3 g of the ethyl ester of Example 22, paragraph 1, in 40 ml of ethanol is treated with 15 ml of a 1 M solution of lithium hydroxide for about 40 hours at 25° C. The mixture is then acidified and extracted well with chloroform. The organic phase is dried and concentrated to afford the title compound.

Workup

  1. extractionextracted well with chloroform
  2. customThe organic phase is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a09998e1758c47558daa3de93d43fe5b
Source dataset
uspto-grants-1981_07
Patent number
US04277395

Reaction notes

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