Sodium hydride → HCID 56621030, compound

HRID 1277356Notes

Reaction equation

HRID 1277356 reaction equation
[N:1]1([C:6](=[CH:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9])[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+]>CO>[N:1]1([C:6](=[CH:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[CH:7]([OH:12])[C:8]([CH3:10])([CH3:11])[CH3:9])[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 54276338HCID 54276338, compound

Product 1

HCID 56621030HCID 56621030, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The product (1.8 g) of Stage 2 was dissolved in dry methanol (20 ml) and sodium hydride (100 mgs) added portionwise to this solution at 0°. After stirring at 0° for 1 hour the methanol was removedin vacuo and the residue washed several times with water to give a white crystalline solid which recrystallised from petroleum ether/ethanol to give the title compound, m.p. 142°-5°.

Workup

  1. washthe residue washed several times with water
  2. customto give a white crystalline solid which
  3. customrecrystallised from petroleum ether/ethanol

Sources & evidence

ORD record
ord-e8b3194ec8e1473789e4117e5116ac1d
Source dataset
uspto-grants-1981_07
Patent number
US04277469

Reaction notes

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