反应详情

A solution of 10.1 g. of 2-acetyl-1,1'-biphenyl in 100 ml. of ethanol containing 7.6 g. of paraformaldehyde, 9.7 g. of dimethylaminium chloride and one drop of concentrated hydrochloric acid was heated to reflux and stirred for sixteen hours. After cooling the reaction mixture to room temperature, the solvent was removed by evaporation. The residue thus formed was crystallized from ethanol and diethyl ether to give 3.6 g of N,N-dimethyl-3-oxo-3-(1,1'-biphenyl-2-yl)propylaminium chloride. M.P. 130°-131° C.

1. temperatureto reflux
2. customthe solvent was removed by evaporation
3. customThe residue thus formed
4. customwas crystallized from ethanol and diethyl ether