HRID1277402

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CSCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)O

HCID12919645

N-(tert-Butoxycarbonyl)-L-tyrosyl-D-methionylglycine

C21H31N3O7S

结构：CC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CN

HCID131712285

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C

HCID12802554

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Using H-Gly-Phe-NHNH-COCH3 (0.44 g) and BOC-(D)-Phe-ONB (0.68 g), the desired compound (0.68 g) is obtained in a similar manner to (III) of Example 45, m.p. 208°-209° C., [α]D23 +3.3°(c=0.45, DMF), Rf1 =0.51.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-36edcd170ca74d10bb2b513f51f15e19
来源数据集: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04277394
来源说明: uspto-grants-1981_07

反应 SMILES

[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][NH:17][C:18]([CH3:20])=[O:19])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[NH:21]([C:46]([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[O:47])[C@H:22]([C:31](N[C@@H](C(NCC(O)=O)=O)CCSC)=[O:32])[CH2:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1>CN(C=O)C>[NH:21]([C:46]([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[O:47])[C@@H:22]([C:31]([NH:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][NH:17][C:18]([CH3:20])=[O:19])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4])=[O:32])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1