Hydrochloric Acid → HCID 178503824, compound

HRID 1277443Notes

Reaction equation

HRID 1277443 reaction equation
Cl.NC1NC=C(CO)N=1.Cl.Cl.NCCS.[NH2:16][C:17]1[NH:18][CH:19]=[C:20]([CH2:22][S:23][CH2:24][CH2:25][NH2:26])[N:21]=1.[N+:27]([CH:30]=[C:31](SC)[S:32][CH3:33])([O-:29])=[O:28]>>[N+:27]([CH:30]=[C:31]([S:32][CH3:33])[NH:26][CH2:25][CH2:24][S:23][CH2:22][C:20]1[N:21]=[C:17]([NH2:16])[NH:18][CH:19]=1)([O-:29])=[O:28]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 9082Cysteamine HydrochlorideHCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 178479151HCID 178479151, compoundHCID 178511470HCID 178511470, compound

Product 1

HCID 178503824HCID 178503824, compound

Procedure

Reaction of 2-amino-4-hydroxymethylimidazole hydrochloride (which is obtained by treating the pierate salt with hydrochloric acid) with cysteamine hydrochloride and reaction of the resulting 2-amino-4-[(2-aminoethyl)thiomethyl]imidazole with 1-nitro-2,2-bis-methylthioethylene according to the procedure of Example 8(i) gives 1-nitro-2-methylthio-2-[2-((2-amino-4-imidazolyl)methylthio)ethylamino]ethylene. Finally, reaction with methylamine by the procedure of Example 8(ii)produces the title compound.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-a18fb5c2b1b447c38a46b4d7f7e9f9a2
Source dataset
uspto-grants-1981_07
Patent number
US04277485

Reaction notes

Loading…