反应详情

A solution of 11.7 g. of 2-methyl-3,4-dibromo-thiophene in 30 ml. of acetic acid was added to 60 ml. of concentrated hydrochloric acid. After dropping in 4.1 g. of a 37% aqueous solution of formaldehyde the mixture was heated to 70° C. for one hour. The reaction mixture was cooled, diluted with water and extracted with ether. The combined organic phases were washed with water, sodium bicarbonate and water, dried over sodium sulfate, filtered and evaporated to give 2-chloromethyl-3,4-dibromo-5-methyl-thiophene.

1. temperatureThe reaction mixture was cooled
2. extractionextracted with ether
3. washThe combined organic phases were washed with water, sodium bicarbonate and water
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customevaporated