A 643C → 2-Amino-N-(1,1-dimethylhexyl)acetamide hydrogen fumarate

HRID 1277496Notes

Reaction equation

HRID 1277496 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[NH2:9][CH2:10][C:11]([NH:13][C:14]([CH3:21])([CH3:20])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:12]>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[NH2:9][CH2:10][C:11]([NH:13][C:14]([CH3:20])([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:12]

Participants

4

Reactant 2

HCID 128299A 643CHCID 444972Fumaric Acid

Product 1

HCID 234541302-Amino-N-(1,1-dimethylhexyl)acetamide hydrogen fumarate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of fumaric acid (12.6 g) in cold methanol (585 mls) was stirred and 2-amino-N-(1,1-dimethylhexyl)acetamide (18.47 g) added to give a clearsolution which rapidly deposited a crystalline solid. After standing at 0° C. for 4 hours this solid was filtered off, washed with ethanol and dried in vacuo, m.p. 154° C.

Workup

  1. customto give a clearsolution which
  2. filtrationthis solid was filtered off
  3. washwashed with ethanol
  4. customdried in vacuo, m.p. 154° C.

Sources & evidence

ORD record
ord-4b82a8312e264f3d80ebbce3c5747447
Source dataset
uspto-grants-1981_07
Patent number
US04277498

Reaction notes

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