反应详情

温度

20 °C

1.5 g of potassium cyanide were added to a mixture of 80 ml of acetonitrileand the solution obtained in Example 9 and the mixture was stirred at 20° C. for 72 hours. Ether was added to the mixture which was then filtered to remove insolubles. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 95-5 cyclohexane-acetone mixture yielded 6.5 g of RS α-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate.

1. filtrationwas then filtered
2. customto remove insolubles
3. customThe filtrate was evaporated to dryness under reduced pressure
4. customthe residue was chromatographed over silica gel
5. washElution with a 95-5 cyclohexane-acetone mixture