Acetic Acid → HCID 20285748, compound

HRID 127754Notes

Reaction equation

HRID 127754 reaction equation
[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:5](C)[CH:6]=1.C=O.[ClH:11].[C:12](O)(=O)[CH3:13]>>[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:12]([CH3:13])[C:6]=1[CH2:5][Cl:11]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 12875260HCID 12875260, compound

Product 1

HCID 20285748HCID 20285748, compound

Procedure

3.04 G. of 2,4-dimethyl-5-chloro-thiophene are dissolved in 60 ml. of acetic acid and 2.1 g. of formalin and 32 ml. of concentrated hydrochloric acid are added. The mixture is stirred at room temperature for 2 hours, then poured into ice water and extracted with hexane. The organic solution is washed with 5% sodium bicarbonate solution, dried, filtered and evaporated to yield 2,4-dimethyl-3-chloromethyl-5-chloro-thiophene.

Workup

  1. extractionextracted with hexane
  2. washThe organic solution is washed with 5% sodium bicarbonate solution
  3. customdried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-8a31c52861ca4158b0ccb4812939e816
Source dataset
uspto-grants-1981_03
Patent number
US04256878

Reaction notes

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