Acetic Anhydride → HCID 23452998, compound

HRID 1277626Notes

Reaction equation

HRID 1277626 reaction equation
[NH2:1][CH2:2][C:3]1[C:4](=[O:17])[NH:5][CH:6]([CH3:16])[N:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:8]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19].O1CCOC[CH2:26]1>>[C:18]([NH:1][CH:2]([C:3]1[C:4](=[O:17])[NH:5][CH:6]([CH3:16])[N:7]([CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:8]=1)[CH3:26])(=[O:20])[CH3:19]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 312751,4-DioxaneHCID 23452994HCID 23452994, compound

Product 1

HCID 23452998HCID 23452998, compound

Procedure

Dry dioxan (80 ml) was added to 6-(1-aminomethyl)-2-benzyl-3-methyl-1,2,4-triazin-5(4H)-one (4.34 g) and the cloudy suspension stirred at room temperature was treated with acetic anhydride (1.9 ml). The mixture was stirred for 2 hours then concentrated to a brown solid. Recrystallisation from ethanol-ether afforded the acetamide, 3.1 g, m.p. 196°-203°.

Workup

  1. stirringThe mixture was stirred for 2 hours
  2. concentrationthen concentrated to a brown solid
  3. customRecrystallisation from ethanol-ether

Sources & evidence

ORD record
ord-8402c6089cf74a8b926b257ba0c9fa24
Source dataset
uspto-grants-1981_07
Patent number
US04278673

Reaction notes

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