Potassium Hydroxide → HCID 12882322, compound

HRID 1277635Notes

Reaction equation

HRID 1277635 reaction equation
[OH-].[K+].[CH:3]1([C:9]2[CH:27]=[CH:26][C:12]([O:13][CH:14]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(O)C>[CH:3]1([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH:14]([CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[C:15]([OH:17])=[O:16])=[CH:26][CH:27]=2)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13020954HCID 13020954, compound

Product 1

HCID 12882322HCID 12882322, compoundYield 44.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into 15 ml of ethanol, 430 mg of potassium hydroxide was dissolved and 1.7 g (0.00512 mole) of ethyl α-(p-cyclohexylphenoxy)α-cyclohexylacetate was added. The mixture was heated on a water bath at 65° to 70° C. for 90 minutes and then ethanol was distilled off under a reduced pressure and the residue was admixed with water and washed twice with benzene. The water layer was acidified with 10% HCl aq.sol. to precipitate a precipitate. The precipitate was filtrated and washed with water and dried. The product was recrystallized from n-hexane to obtain 0.7 g of α-(p-cyclohexylphenoxy)α-cyclohexylacetic acid (yield: 44.9%).

Workup

  1. temperatureThe mixture was heated on a water bath at 65° to 70° C. for 90 minutes
  2. distillationethanol was distilled off under a reduced pressure
  3. washwashed twice with benzene
  4. customto precipitate a precipitate
  5. filtrationThe precipitate was filtrated
  6. washwashed with water
  7. customdried
  8. customThe product was recrystallized from n-hexane

Sources & evidence

ORD record
ord-1c16c4ef1a4a460b8622e0c44209e1e8
Source dataset
uspto-grants-1981_07
Patent number
US04278678

Reaction notes

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