Dichloromethane → HCID 23453199, compound

HRID 1277657Notes

Reaction equation

HRID 1277657 reaction equation
[N:1]1([CH:6]([CH3:12])[C:7]([O:9][CH2:10][CH3:11])=[O:8])C=[CH:4][CH:3]=[CH:2]1.S(Cl)([Cl:16])(=O)=O.Cl[CH2:19][Cl:20]>>[Cl:16][C:2]1[N:1]([CH:6]([CH3:12])[C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:19]([Cl:20])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24648Sulfuryl chlorideHCID 14351973HCID 14351973, compound

Product 1

HCID 23453199HCID 23453199, compound

Procedure

Ethyl 2-(1H-pyrrol-1-yl)propionate (Ger. Offen. No. 2,305,632) in dichloromethane, maintained below 0° C., is treated with two equivalents of sulphuryl chloride to give ethyl 2-(2,5-dichloro-1H-pyrrol-1-yl)propionate. Treatment of this ester with ammonia in the manner of Example 1, gives 2-(2,5-dichloro-1H-pyrrol-1-yl)propionamide.

Sources & evidence

ORD record
ord-64c5808e168d45d28f2230fc949eeee2
Source dataset
uspto-grants-1981_07
Patent number
US04278685

Reaction notes

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