Water → HCID 23453416, compound

HRID 1277733Notes

Reaction equation

HRID 1277733 reaction equation
CCO[C:4]([CH2:6][CH2:7][CH2:8][P:9]([O:14]CC)([O:11]CC)=[O:10])=O.[C:17]1([NH2:24])[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH2:23].O>Cl>[N:23]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[NH:24][C:4]=1[CH2:6][CH2:7][CH2:8][P:9]([OH:11])(=[O:10])[OH:14]

Participants

5

Reactant 3

HCID 962WaterHCID 7243O-PhenylenediamineHCID 281201Ethyl 4-(diethoxyphosphoryl)butanoate

Product 1

HCID 23453416HCID 23453416, compoundYield 51.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

If 110 g (0.43 mol) of triethyl 4-phosphonobutyrate and 48.6 g (0.45 mol) of o-phenylenediamine are reacted with one another in 200 g of concentrated HCl and 200 g of H2O according to Example 1, 52.5 g (51.5% of theory) of 3-[benzimidazol-2-yl]-propanephosphonic acid are obtained as light grey crystals with a melting point of about 280° C. (decomposition). ##STR19##

Sources & evidence

ORD record
ord-96034c52eaf84c2491f459c3af6b8fb0
Source dataset
uspto-grants-1981_07
Patent number
US04278791

Reaction notes

Loading…