2-Chloroethanol → 3-(2-Chloroethoxy)-2-ethylacrylic acid methyl ester

HRID 1277737ノート

反応式

HRID 1277737 の反応式
[CH3:1][O:2][C:3](=[O:9])[CH:4]([CH:7]=[O:8])[CH2:5][CH3:6].[Cl:10][CH2:11][CH2:12]O>C1C=CC=CC=1.S(=O)(=O)(O)[O-].[Na+]>[CH3:1][O:2][C:3](=[O:9])[C:4]([CH2:5][CH3:6])=[CH:7][O:8][CH2:12][CH2:11][Cl:10]

参加物

5

反応物 2

HCID 342-ChloroethanolHCID 15570303Methyl 2-formylbutanoate2 回

生成物 1

HCID 537981423-(2-Chloroethoxy)-2-ethylacrylic acid methyl ester収率 82.4%

試薬・触媒・溶媒 2

HCID 516919Sodium Bisulfate触媒HCID 241Benzene溶媒

実験手順

35 g 2-Formyl-butyric acid methyl ester (0.27 mole) was dissolved in 250 ml benzene, and the solution was mixed with 26 g 2-chloroethanol (0.324 mole) and 700 mg sodium bisulfate. The mixture was refluxed for 18 hours, and the water formed during the reaction was withdrawn continuously. After removal of the solvent by distillation, the residue was fractionated in a vacuum and 42.8 g (44.2 g) 3-(2-chloroethoxy)-2-ethylacrylic acid methyl ester boiling at 99°-101° C./3 torr was obtained (82.4%-85% yield). nD23 =1.4770.

後処理

  1. temperatureThe mixture was refluxed for 18 hours
  2. customwas withdrawn continuously
  3. customAfter removal of the solvent
  4. distillationby distillation

出典と根拠

ORDレコード
ord-1b302f29424e406b8874caa32686873f
出典データセット
uspto-grants-1981_07
特許番号
US04278808

反応ノート

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