反应详情

35 g 2-Formyl-butyric acid methyl ester (0.27 mole) was dissolved in 250 ml benzene, and the solution was mixed with 26 g 2-chloroethanol (0.324 mole) and 700 mg sodium bisulfate. The mixture was refluxed for 18 hours, and the water formed during the reaction was withdrawn continuously. After removal of the solvent by distillation, the residue was fractionated in a vacuum and 42.8 g (44.2 g) 3-(2-chloroethoxy)-2-ethylacrylic acid methyl ester boiling at 99°-101° C./3 torr was obtained (82.4%-85% yield). nD23 =1.4770.

1. temperatureThe mixture was refluxed for 18 hours
2. customwas withdrawn continuously
3. customAfter removal of the solvent
4. distillationby distillation