Hydrochloric Acid → HCID 12832224, compound

HRID 1277804Notes

Reaction equation

HRID 1277804 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:19])[C:14](=[CH:17][CH:18]=2)[C:15]#N)[CH:8]=[CH:9][CH:10]=1)(=O)C.[OH-:20].[K+].Cl.[OH-:23].[Na+]>O>[NH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:19])[C:14](=[CH:17][CH:18]=2)[C:15]([OH:23])=[O:20])[CH:8]=[CH:9][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 12918955HCID 12918955, compound

Product 1

HCID 12832224HCID 12832224, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 92.5 g (0.37 mol) of 6-(3-acetylaminophenyl)-1,2-dihydro-2-oxonicotinonitrile, 185 g of potassium hydroxide, and 740 ml of water was heated at 105° for 30 hrs. The cooled reaction mixture was poured into 285 ml of concentrated hydrochloric acid and ice. The pH of the suspension was adjusted to 5.0 with aqueous sodium hydroxide solution and the solid filtered, washed with water, and dried to give 81.2 g of 6-(3-aminophenyl)-1,2-dihydro-2-oxonicotinic acid. ##EQU21##

Workup

  1. temperaturewas heated at 105° for 30 hrs
  2. customThe cooled reaction mixture
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-dc5481bde3ea4658ae31148eb5736d8c
Source dataset
uspto-grants-1981_07
Patent number
US04278681

Reaction notes

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