2,2-Dimethoxyethylmethylamine → HCID 13020005, compound

HRID 1277831Notes

Reaction equation

HRID 1277831 reaction equation
C(O[C:4](=[O:23])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)=[CH:8][CH:7]=1)C.[CH3:24][O:25][CH:26]([O:30][CH3:31])[CH2:27][NH:28][CH3:29]>>[F:22][C:19]([F:20])([F:21])[C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[O:12][C:9]1[CH:8]=[CH:7][C:6]([NH:5][C:4]([N:28]([CH2:27][CH:26]([O:30][CH3:31])[O:25][CH3:24])[CH3:29])=[O:23])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 85032,2-DimethoxyethylmethylamineHCID 13020003HCID 13020003, compound

Product 1

HCID 13020005HCID 13020005, compound

Conditions

Temperature
120 °C

Procedure

Ethyl[4-[3-(trifluoromethyl)phenoxy]-phenyl]carbamate (7.1 grams; 0.02 mol) and N-(2,2-dimethoxyethyl) methanamine (15 ml) were charged into a glass reaction vessel equipped with mechanical stirrer, thermometer and reflux condenser. The mixture was refluxed for about 36 hours at a temperature of about 120° C. The product was recrystallized from ethyl acetate, then recrystallized from hexane giving the desired product having a melting point of 86°-88° C.

Workup

  1. customequipped with mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. customThe product was recrystallized from ethyl acetate
  4. customrecrystallized from hexane giving the desired product

Sources & evidence

ORD record
ord-bbe81559c62d4607a26ce3847226656c
Source dataset
uspto-grants-1981_07
Patent number
US04279637

Reaction notes

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