反应详情

N-[4-(4-Nitrophenoxy)-3-nitrophenyl]-N'-(2,2-dimethoxyethyl)-N'-methylurea (0.02 mole), water (30 ml) and concentrated hydrochloric acid (3 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and condenser. The mixture is refluxed for a period of about 30 minutes then cooled and extracted with ethyl acetate. The extract is washed with dilute aqueous sodium bicarbonate, with two portions of water and is then dried. The ethyl acetate is removed by mild warming under reduced pressure to yield the desired product 1-methyl-3-[4-(4-nitrophenoxy)-3-nitrophenyl]-4-imidazolin-2-one.

1. customfitted with a mechanical stirrer
2. temperatureThe mixture is refluxed for a period of about 30 minutes
3. temperaturethen cooled
4. extractionextracted with ethyl acetate
5. washThe extract is washed with dilute aqueous sodium bicarbonate, with two portions of water
6. customis then dried
7. customThe ethyl acetate is removed
8. temperatureby mild warming under reduced pressure