Morpholine → 4-[(4-Iodophenyl)carbonyl]morpholine

HRID 1277915Notes

Reaction equation

HRID 1277915 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[I:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][CH:9]=1>CCOCC>[I:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[O:13])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 743734-Iodobenzoyl chloride

Product 1

HCID 7726344-[(4-Iodophenyl)carbonyl]morpholine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 15 ml of morpholine in 20 ml of ether was reacted with a solution of 5.4 g p-iodobenzoyl chloride in 20 ml ether. The excess organic solvent was removed and the crude product recovered as described in Example 3. After recrystallization there was obtained 3.1 g of N-p-iodobenzoyl-morpholine as translucent crystals, m.p. 116°-117°, Rf 0.72.

Workup

  1. customThe excess organic solvent was removed
  2. customthe crude product recovered
  3. customAfter recrystallization

Sources & evidence

ORD record
ord-3e7eb16aa59f40e7b82684b3bde40b80
Source dataset
uspto-grants-1981_07
Patent number
US04279887

Reaction notes

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