反应详情

1.27 g of 6-(3,5-dichloro-4-methylphenyl)-3-pyridazone and 1.12 g of triethylenediamine were dissolved in 25 ml of hexamethylphosphoric triamide, and then 1.5 g of morpholinocarbonyl chloride were added dropwise thereto. When the addition was complete, the mixture was stirred at room temperature for 1 hour and then poured into about 200 g of ice-water. The precipitate thus produced was collected by filtration, washed with water and dried, giving 1.75 g (94%) of the desired Compound No. 10. The melting point and spectroscopic data of this product agreed completely with those of the product obtained in Example 2.

1. additionWhen the addition
2. customThe precipitate thus produced
3. filtrationwas collected by filtration
4. washwashed with water
5. customdried