反应详情

A mixture of 2.55 g of 6-(3,5-dichloro-4-methylphenyl)-3-pyridazone, 4.7 g of methyl chloroformate and 25 ml of xylene was heated under reflux for 1.5 hours. The reaction mixture was then left to cool at room temperature and the precipitate thus produced was collected by filtration and washed with hexane, giving 2.94 g (94%) of the desired Compound No. 23 in the form of colourless prisms having, after recrystallization from benzene, a melting point of 203°-206° C.

1. temperaturewas heated
2. temperatureunder reflux for 1.5 hours
3. waitThe reaction mixture was then left
4. customthe precipitate thus produced
5. filtrationwas collected by filtration
6. washwashed with hexane