Hydrochloric Acid → HCID 12763992, compound

HRID 1277952Notes

Reaction equation

HRID 1277952 reaction equation
[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[C:14]([O:16]CC)=[O:15])=[CH:10][CH:9]=[CH:8][CH:7]=3.[OH-].[Na+].Cl>C(O)C.O>[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[C:14]([OH:16])=[O:15])=[CH:10][CH:9]=[CH:8][CH:7]=3

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12763955HCID 12763955, compound

Product 1

HCID 12763992HCID 12763992, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

0.5 g of ethyl imidazo-[1,2-a]-quinoline-2-carboxylate was dissolved in 50 ml of ethanol and then a solution of 0.12 g of sodium hydroxide in 10 ml of water was added thereto. The mixture was heated on a steam bath for 2 hours and was subsequently acidified to a pH of 2 with concentrated hydrochloric acid. The mixture was evaporated to dryness under reduced pressure and 50 ml of methanol were added to the residue. The solution was filtered to remove inorganic material and the filtrate was evaporated to dryness under reduced pressure. The residue was crystallized by trituration in chloroform to give imidazo-[1,2-a]-quinoline-2-carboxylic acid in the form of the hydrochloride salt.

Workup

  1. temperatureThe mixture was heated on a steam bath for 2 hours
  2. customThe mixture was evaporated to dryness under reduced pressure and 50 ml of methanol
  3. additionwere added to the residue
  4. filtrationThe solution was filtered
  5. customto remove inorganic material
  6. customthe filtrate was evaporated to dryness under reduced pressure
  7. customThe residue was crystallized by trituration in chloroform

Sources & evidence

ORD record
ord-2a9e9bfa00244450a82f0e6cc8700b33
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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