反应详情

1.35 g of ethyl 8-methoxyimidazo-[1,2-a]-quinoline-2-carboxylate were dissolved in 60 ml of ethanol and 2.5 ml of 2 N sodium hydroxide were added thereto. The mixture was refluxed for 1 hour whereupon a colorless gel was produced and after 3 ml of 2 N hydrochloric acid were added, and the mixture was refluxed for another 60 minutes and then was allowed to cool to room temperature. The cream precipitate thus formed was filtered off and was recrystallized from glacial acetic acid and then was washed with methanol to obtain off-white crystals of 8-methoxyimidazo-[1,2-a]-quinoline-2-carboxylic acid melting at 272°-273° C.

1. temperatureThe mixture was refluxed for 1 hour whereupon a colorless gel
2. customwas produced
3. temperaturethe mixture was refluxed for another 60 minutes
4. customThe cream precipitate thus formed
5. filtrationwas filtered off
6. customwas recrystallized from glacial acetic acid
7. washwas washed with methanol