HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylene Oxide → Ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | 2-Amino-4,7-dichloroquinoline | HCID 14067408 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate | HCID 12763976 | — |
Reaction Steps
1.8 g of 2-amino-4,7-dichloroquinoline [Hardman and Partridge J.C.S. (1958) p. 641] were reacted with 2.1 g of ethyl bromopyruvate in 60 ml of dimethoxyethane in the presence of 0.7 g of propylene oxide by the method of Example 9 to obtain ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate as fine colorless needles melting at 229°-230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04279912 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-eea6977d94a749b6a02e0958c08d254b |
| Source note | uspto-grants-1981_07 |