Hydrochloric Acid → HCID 70568667, compound

HRID 1277968Notes

Reaction equation

HRID 1277968 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=[C:7]1[CH:6]=[CH:5]2.Cl>C(O)C.[OH-].[Na+].O>[OH2:16].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=[C:7]1[CH:6]=[CH:5]2

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 12763978HCID 12763978, compound

Product 1

HCID 70568667HCID 70568667, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

820 mg of ethyl 7-chloroimidazo-[1,2-a]-quinoline-2-carboxylate in 25 ml of ethanol and 1 N sodium hydroxide solution was added thereto. The mixture obtained was heated on a steam bath for 30 minutes and then was diluted with 50 ml of water. The mixture was neutralized with 3.5 ml of 2 N hydrochloric acid and then cooled to obtain pale cream crystals of 7-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid monohydrate melting at 278°-279° C. The I.R. spectrum suggests that the compound exists at least partially in the zwitterionic form.

Workup

  1. customThe mixture obtained
  2. temperaturewas heated on a steam bath for 30 minutes
  3. temperaturecooled

Sources & evidence

ORD record
ord-e6be0407b1794ffda51d2777a2395453
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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