Hydrochloric Acid → HCID 70570348, compound

HRID 1277977Notes

Reaction equation

HRID 1277977 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]2[CH:18]=1)=[O:5])C.O.[OH-].[Na+].Cl>C(O)C>[OH2:3].[CH:18]1[N:9]2[C:10]3[C:15]([CH:16]=[CH:17][C:8]2=[N:7][C:6]=1[C:4]([OH:5])=[O:3])=[CH:14][CH:13]=[CH:12][CH:11]=3

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 12763955HCID 12763955, compound

Product 1

HCID 70570348HCID 70570348, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g of ethylimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in 40 ml of ethanol and 20 ml of water and 9 ml of N NaOH were added. The mixture was heated on a steam bath for 30 minutes and the hot solution was acidified with 9.5 ml of N hydrochloric acid. The mixture was cooled slowly to room temperature and then in ice to give colorless needles of imidazo-[1,2-a]-quinoline-2-carboxylic acid monohydrate melting at 234°-236° C. The I.R. spectrum suggested that the compound existed partially in the zwitterionic form.

Workup

  1. temperatureThe mixture was heated on a steam bath for 30 minutes

Sources & evidence

ORD record
ord-538e3759f3e14620bfe1fdaa8d7ebd06
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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