Hydrochloric Acid → HCID 12763969, compound

HRID 1277980Notes

Reaction equation

HRID 1277980 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]2[CH:14]=[C:15]([C:17]([O:19]CC)=[O:18])[N:16]=[C:4]2[CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]2[CH:14]=[C:15]([C:17]([OH:19])=[O:18])[N:16]=[C:4]2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12763970HCID 12763970, compound

Product 1

HCID 12763969HCID 12763969, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

600 mg of ethyl 5-chloro-8-methoxyimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in 100 ml of 50% aqueous ethanol and then 4.4 ml of N sodium hydroxide solution were added. The mixture was heated on a steam bath for 1 hour and the resulting solution was acidified with 4.4 ml of N hydrochloric acid and then was cooled to room temperature to obtain colorless crystals of 5-chloro-8-methoxy-imidazo-[1,2-a]-quinoline-2-carboxylic acid melting at 277°-278° C.

Workup

  1. temperatureThe mixture was heated on a steam bath for 1 hour

Sources & evidence

ORD record
ord-11d19d5c12dc4b8fbf33eb2c7b40b3da
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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