Ethylamine → HCID 178483236, compound

HRID 1278000Notes

Reaction equation

HRID 1278000 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15](SC)=[N:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:7][CH:6]=1)[CH3:3].[CH2:23]([NH2:25])[CH3:24]>>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:25][CH2:23][CH2:24][S:11][CH2:10][C:8]2[O:9][CH:5]=[CH:6][CH:7]=2)=[N:16][S:17]([CH3:20])(=[O:18])=[O:19])=[CH:7][CH:6]=1)[CH3:1]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 178504070HCID 178504070, compound

Product 1

HCID 178483236HCID 178483236, compoundYield 184.5%

Procedure

A mixture of N-[2-[[5-[(dimethylamino)methyl]-2-furanylmethyl]thio]ethyl]-N'-methylsulphonylcarbamimidothioic acid, methyl ester (1.82 g) and 2-(2-furanylmethyl)thio]ethanamine (0.785 g) was heated at 120° for 5 hours. The reaction mixture was chromatographed (silica/ethyl acetate-methanol 3:1) and the appropriate eluate evaporated to dryness to give the title compound (2.18 g), as a yellow oil.

Workup

  1. temperaturewas heated at 120° for 5 hours
  2. customThe reaction mixture was chromatographed (silica/ethyl acetate-methanol 3:1)
  3. customthe appropriate eluate evaporated to dryness

Sources & evidence

ORD record
ord-e86afbbc29bc475f8cf5b8c5d9f5eb07
Source dataset
uspto-grants-1981_07
Patent number
US04279911

Reaction notes

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