反应详情

46.3 g of 2,2-dimethyl-1,3-dioxolane-4-methanol (0.35 mol) (Aldrich) is cooled to 0° in an ice bath and under a nitrogen atmosphere 2.1 g of sodium hydride (0.088 mol) (washed with hexane to remove the mineral oil) is slowly added to the rapidly stirred mixture. The addition of the sodium hydride is made at such a rate that the temperature remains below 20°. After the addition of the NaH has been completed the mixture is allowed to stir for 1/2 hour and slowly warmed to room temperature. Slowly, and with stirring 10.0 g of 1,5-hexadiene diepoxide (0.088 mol) is added to the mixture. After the addition of the diepoxide has been completed the reaction mixture is heated at reflux for 16 hours. The mixture is then cooled to room temperature and with stirring is poured into 350 ml of water. The aqueous mixture is extracted with two 200 ml portions of chloroform, the CHCl3 extracts are combined and dried over anhydrous sodium sulfate. The CHCl3 is removed in vacuo and the dark brown residue then vacuum distilled through a 10 cm vigreux distilling column. The fraction boiling at 135°-137° @ 0.3 mm is collected yielding 12.6 g (58%) of the above compound.

1. washwashed with hexane
2. customto remove the mineral oil)
3. additionis slowly added to the rapidly stirred mixture
4. additionThe addition of the sodium hydride
5. customremains below 20°
6. additionAfter the addition of the NaH
7. additionis added to the mixture
8. additionAfter the addition of the diepoxide
9. temperatureis heated
10. temperatureat reflux for 16 hours
11. temperatureThe mixture is then cooled to room temperature
12. stirringwith stirring
13. extractionThe aqueous mixture is extracted with two 200 ml portions of chloroform
14. dry with materialdried over anhydrous sodium sulfate
15. customThe CHCl3 is removed in vacuo
16. distillationthe dark brown residue then vacuum distilled through a 10 cm
17. distillationvigreux distilling column
18. customThe fraction boiling at 135°-137° @ 0.3 mm is collected