2-(p-Chlorobenzylidene)-1-methylpyrrolidine → 2-[(4-Chlorophenyl)methyl]-1-methylpyrrolidine

HRID 1278027Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278027
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH:6]=[C:7]2[CH2:11][CH2:10][CH2:9][N:8]2[CH3:12])=[CH:4][CH:3]=1>CO.[Ni]>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][CH:7]2[CH2:11][CH2:10][CH2:9][N:8]2[CH3:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 540151972-(p-Chlorobenzylidene)-1-methylpyrrolidine

Produkt 1

HCID 234525052-[(4-Chlorophenyl)methyl]-1-methylpyrrolidineAusbeute 80,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Dissolve 28 g of 2-(p-chlorobenzylidene)-1-methylpyrrolidine in 250 ml of methanol and hydrogenate the thus-obtained solution with Raney nickel as catalyst. Filter the catalyst from the hydrogenated product and then concentrate the filtrate to obtain 22.7 g of the title compound having a boiling point of 75° at 0.005 millimeters (mm) of Hg (yield: 81% of theory). The picrate (from ethanol) melts at 149°.

Aufarbeitung

  1. filtrationFilter the catalyst from the hydrogenated product
  2. concentrationconcentrate the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-af40e7df989b4d8f8f6a3f604fb9bdac
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04279918

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