HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(p-Chlorobenzylidene)-1-methylpyrrolidine → 2-[(4-Chlorophenyl)methyl]-1-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(p-Chlorobenzylidene)-1-methylpyrrolidine | HCID 54015197 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(4-Chlorophenyl)methyl]-1-methylpyrrolidine | HCID 23452505 | 80.3% |
Reaction Steps
Dissolve 28 g of 2-(p-chlorobenzylidene)-1-methylpyrrolidine in 250 ml of methanol and hydrogenate the thus-obtained solution with Raney nickel as catalyst. Filter the catalyst from the hydrogenated product and then concentrate the filtrate to obtain 22.7 g of the title compound having a boiling point of 75° at 0.005 millimeters (mm) of Hg (yield: 81% of theory). The picrate (from ethanol) melts at 149°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04279918 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-af40e7df989b4d8f8f6a3f604fb9bdac |
| Source note | uspto-grants-1981_07 |