Pyrrolidine → HCID 23452506, 화합물

HRID 1278036노트

반응식

HRID 1278036 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH:6]=[C:7]1[CH2:11][CH2:10][CH2:9][N:8]1[CH3:12].N1CCCC1>CO.[Ni].[H][H]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH2:6][CH:7]1[CH2:11][CH2:10][CH2:9][N:8]1[CH3:12]

참가 물질

5

반응물 2

HCID 31268PyrrolidineHCID 544128563,4-Dimethoxybenzylidene-1-methylpyrrolidine

생성물 1

HCID 23452506HCID 23452506, 화합물수율 79%

시약·촉매·용매 2

HCID 178506447HCID 178506447, 화합물촉매HCID 887Methanol용매

실험 절차

Dissolve 12.2 g of 3,4-dimethoxybenzylidene-1-methylpyrrolidine in methanol and reduce the pyrrolidine in the thus-obtained solution with Raney nickel/hydrogen. Filter off the catalyst and distil off the methanol before distilling the residue to obtain 9.6 g (79%) of the title compound with a b.p. of 90° at 0.005 mm of Hg. The m.p. of the picrate (from ethanol) is 105° to 106°.

후처리

  1. filtrationFilter off the catalyst
  2. customdistil off the methanol
  3. distillationbefore distilling the residue

출처 및 근거

ORD 기록
ord-50bb44cd69934f1291e4200fcbddc942
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04279918

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