反应详情

Add (dropwise at 90°, with stirring, in a stream of nitrogen) a solution of 2.6 g of sodium in 50 ml of ethanol to 34.5 g of 2-dimethylamino-1-benzyl-1-pyrroliniummethylsulfate and 19.7 g of homoveratric acid ethyl ester. Keep the resulting reaction mixture at this temperature for a further 30 minutes and then distribute it between water and diethyl ether. Dry the ether solution over sodium sulfate and then concentrate it to obtain a yield [32.2 g (96% of theory)] of title compound.

1. additionAdd (dropwise at 90°
2. customthe resulting reaction mixture at this temperature for a further 30 minutes
3. dry with materialDry the ether solution over sodium sulfate
4. concentrationconcentrate it
5. customto obtain