HCID 13186905, compound → 4-[(1-Methylpyrrolidin-2-yl)methyl]aniline

HRID 1278046Notes

Reaction equation

HRID 1278046 reaction equation
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][N:10]2[CH3:14])=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pt](=O)=O.[H][H]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][N:10]2[CH3:14])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 13186905HCID 13186905, compound

Product 1

HCID 131869044-[(1-Methylpyrrolidin-2-yl)methyl]aniline

Reagents, catalysts & solvents 2

HCID 178506448HCID 178506448, compoundCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate 18 g of 2-(4-nitrobenzyl)-1-methylpyrrolidine in ethanol with 300 mg of platinum dioxide/hydrogen. Filter the catalyst from the reaction mixture, concentrate the latter and recrystallize the thus-produced residue from n-hexane to obtain the title compound at a yield of 12.7 g (82% of theory).

Workup

  1. filtrationFilter the catalyst from the reaction mixture
  2. concentrationconcentrate the latter and
  3. customrecrystallize the thus-produced residue from n-hexane

Sources & evidence

ORD record
ord-1cb7867abf4a4a23b6ea281998cc6f6b
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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