Water → HCID 23452543, compound

HRID 1278071Notes

Reaction equation

HRID 1278071 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:18]=[CH:17][C:9]([CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])=[CH:8][CH:7]=1.C(N(CC)CC)C.O>C1C=CC=CC=1.C(OCC)C>[C:1]([NH:5][C:6]1[CH:18]=[CH:17][C:9]([CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][N:12]2[CH3:16])=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 131869044-[(1-Methylpyrrolidin-2-yl)methyl]aniline

Product 1

HCID 23452543HCID 23452543, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

Add a solution of 0.78 g of acetyl chloride in 5 ml of benzene dropwise to a solution of 1.9 g of 2-(4-aminobenzyl)-1-methylpyrrolidine and 1 g of triethylamine in 10 ml of benzene. After one hour, concentrate the resulting reaction mixture. Then take it up with water and diethyl ether. Collect the organic phase and concentrate it to obtain the title compound as a yellowish oil.

Workup

  1. concentrationconcentrate
  2. customthe resulting reaction mixture
  3. customCollect the organic phase
  4. concentrationconcentrate it

Sources & evidence

ORD record
ord-d9c1a7e3de9a4c2f98bdb677b19bd3ac
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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